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Opportunities exist to make use of natural pathways for delivery of therapeutic entities, in particular to develop safe and effective methods for gene therapy, although past attempts to design non-viral nuclear delivery systems have met with limited success.
Recombinant enzymes are large molecules that do not freely diffuse across membranes and depend on the mannose or MPR pathways for delivery to lysosomes.
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Some of them such as the Type II and V systems depend on the activity of the sec pathway for delivery of their substrate proteins into the periplasm, whereas the remaining systems (type I, III, IV, VI, VII) are able to directly pick proteins from the cytosol [ 101].
These existing import and export pathways could potentially be the pathways for substrate delivery to the IMS ribonuclease activity.
Using multiple pathways for electricity delivery alleviates the imbalance of resource allocation, so that generation resource utilization can be more efficient.
Multiple system configurations, representative of different pathways for the delivery of consistent food products are evaluated, transforming a once linear product system into a circular design.
We present increasing evidence for the existence of parallel pathways for the delivery of newly synthesized lysosomal proteins directly from the trans-Golgi network (TGN) to the endo-lysosomal system.
Phosphorus export via erosion and leaching was the dominant pathway for P delivery to rivers.
Antimicrobial medical device combination products provide a pathway for local delivery of antimicrobial therapeutics with the ability to achieve high local concentrations while minimizing systemic side effects.
Storm surges transport sandy and muddy littoral and shallow offshore sediments hundreds to thousands of meters inland, and represent an important pathway for sediment delivery into the interior of coastal marshes.
These high levels are likely due to enhanced autophagy, a presumed pathway for glycogen delivery to the lysosomes.
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