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These results demonstrate the utility of the ActiveGEnSeMBLE method for predicting multiple conformations along the pathways for activating GPCRs and the corresponding energy landscapes, thereby providing detailed structural insights into the initial molecular events of GPCR function that are not easily accessible by experiments.
Creating focal lesions in primary visual cortex (V1) provides an opportunity to study the role of extra-geniculo-striate pathways for activating extrastriate visual cortex.
Several pathways for activating caspases exist.
Currently, two pathways for activating caspases have been studied in detail, that is the mitochondrial 'intrinsic' pathway and the transmembrane 'extrinsic' pathway.
In addition to differentially expressed genes, various signal transduction pathways for activating or repressing numerous gene sets are also involved in the process of embryogeny acquisition [ 7].
Leucine and insulin share common pathways for activating protein synthesis, suggesting that signal transduction is impaired somewhere within the mammalian target of rapamycin pathway.
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The work would be of much greater impact if the authors could use any other molecular distinction to show that GalNAc T1 and KDEL-R really do use different activation pathways for activated retrograde transport.
In addition, we have previously demonstrated, the induction of STAT3 signaling in APCs upon cell contact with hMSC, suggesting a new pathway for activating STAT3 in APCs.
Taken together, PA might activate PKCα pathway for activating autophagy in hepatocytes.
Blocking mTOR signaling is the best pathway for activating autophagy [ 32].
Ligand-dependent S2152 phosphorylation by a variety of FLNa ligands may be a novel pathway for activating filamin function in diverse filamin-mediated cellular processes.
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