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The protein targets were associated with 176 human related pathways extracted from the KEGG database [16].
Using groups of Associated Genes of interest (as determined by well known sub-units [69], pathways extracted from the literature [66] and KEGG [70], [71] and Reactome [72], [73], [74] databases) as primary nodes – networks were built to examine the interactions between the given associated gene set at the microRNA level.
Twenty miRNAs of interest were built determined by pathways extracted from KEGG as primary nodes-networks.
Figure 1C shows how node count varies with gene count in pathways extracted from PID.
Figure 5 outlines the metabolic pathways extracted from the complete metabolic network that are required for mycobactin synthesis.
For comparison, we performed the same analysis using pathways extracted from the human metabolic model of the BiGG database (see Additional file 1: Table S1).
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Several examples of simple BioPAX Level 3 files imported through BiNoM, representing different types of interactions, are shown on Figure 1. Figure 2 shows the hierarchical structure of the human apoptosis pathway, extracted from Reactome database, and constructed by BiNoM.
The questionnaire asked for confirmation of the diagnosis and a detailed description of the patient's diagnostic pathway extracted from the electronic medical record and discharge letters from hospitals and specialists (e.g. dates of reported symptoms, encounters, tests, referrals and involvement of other providers).
When pathways are extracted from Pathway Miner, the levels of gene expression can be discerned, but four samples could be shown at a time.
Networks representing the full metabolism of E. coli K12 MG1255 have been constructed from the following sources: the EcoCyc [ 26] pathways were extracted from the pathways.dat file contained in the flat-file distribution (EcoCyc version 13.6).
For each P450 and data set co-expressed genes with r > 0.5 were retrieved and the corresponding biochemical pathways were extracted from the pathway database (see above).
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