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This article will focus principally on the signaling pathways engaged by the neurotrophin family of neurotrophic factors.
Our data suggests that the pathways engaged by mutant RAS that promote tumor formation show differences that are possibly inherent to each tissue or tumor type.
Understanding the signaling pathways engaged by oncogenic RAS in promoting malignant transformation is fundamental to identifying and targeting components downstream of RAS.
Our published study [36] has reported that in multiple cell types the signaling pathways engaged by several physiological stimuli converge upon LKB1 phosphorylation at S307, which directs the nucleocytoplasmic transport of LKB1 and consequent AMPK activation.
Additionally, the experimental design allowed us to test whether the neural pathways engaged when we view objects in normal settings are significantly different from those engaged when we view them in abnormal ones, irrespective of aesthetic ratings.
There are many proteins modified and many signaling pathways engaged.
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It is possible that multiple redundant pathways engage at larger ΔT to generate the thermally induced avoidance response.
The findings summarized above suggest that abscission-associated carbohydrate-, ethylene- and auxin-responsive signaling pathways engage in crosstalk with each other and with other signaling pathways to coordinate abscission.
Two major DNA repair pathways engage with DSBs: non-homologous end joining (NHEJ) fuses broken chromosome ends together, whereas homologous recombination (HR) uses sequence homology to repair DSBs (Frank-Vaillant and Marcand, 2002; Kim et al, 2005).
However, understanding how intracellular signaling pathways engage with the core transcription factor circuitry to maintain or extinguish pluripotency remains fragmentary (Chen et al., 2008; Jaenisch and Young, 2008; Nichols and Smith, 2012; Niwa et al., 2009).
The last major pathway engaged by NPM ALK is the JAK/STAT pathway.
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