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The measurement of dysfunctions of pathways during a phenotype change, e.g., from normal to diseased, is the key issue when applying enrichment analysis for pathway or other functional gene set.
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Methods: As part of a clinical pathway, during a 15 month period, patients with BMI ≥ 30 kg/m2 in select medical services were screened with a validated sleep questionnaire.
Important concepts that are illustrated by these model systems include the ideas of conformational change both close to and at a distance from the triggering event, and the formation of a transitory water-linked proton pathway during a catalytic cycle.
Our results show a requirement for suppression, or low activity, of Wnt/β-catenin pathway during a period of several hours just prior to the onset of cadiomyocyte differentiation.
In order to understand the efficacy of the cold-inducible three-component system, a time course of gene expression was determined for transgenes and genes encoding the flavonoid biosynthesis pathway during a long-term cold induction (Figure 4).
The partial blockade of this pathway during a hyperactive Th2 immune response may reduce Th2 cytokine production without completely debilitating the immune response, allowing the immune system to maintain a normal immune response against pathogens.
Counterintuitive or not, the study may have uncovered individuals susceptible to adverse outcomes stemming from overactivity in the folate metabolism pathway during a critical stage of embryonic neurodevelopment.
We conditionally activated the Wnt pathway during a defined stage in larval development by expressing a gain-of-function, truncated version of BAR-1 beta catenin from the heat shock promoter.
But from another point of view, modification of HMGB1 (and possibly of other DAMPs) could be caused by activation of a certain biochemical pathway during a specific cell death modality.
It is known that in some CH patients there is a dysfunction in the cervical sympathetic pathway during an attack which leads to a disturbance in sympathetic vasoconstrictor tone and causes the classic features of ptosis and miosis [15].
The Jak-Stat pathway has been shown to affect the course of Drosophila C virus infection [1], and there is some evidence for a role of the Toll pathway during an infection with the Drosophila X virus [2].
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