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These pathways are termed "direct" and "indirect". Before continuing, you may want to take a moment to review these two pathways described here, in the Neurobiology of HD section.
In addition, many of the genes and pathways described here, e.g. those involved in signal transduction and sulfur metabolism, have been identified previously within the epsilon subdivision only in S. denitrificans, W. succinogenes, Sulfurovum, and/or Nitratiruptor, or are unique to the subdivision.
To establish a hierarchy in the silencing pathways described here, we asked whether nuclear RNAi/chromatin components are upstream or downstream of secondary siRNA expression and/or stability.
The pathways described here are of central importance to understanding macrophage biology and therefore innate immunity, and the diagram provides a consensus view of these systems.
The novel FLS invasion pathways described here resemble those described in cancer cell lines and have the potential to become novel targets for therapeutic intervention.
The extent, however, to which the psychosocial pathways described here also relate to other symptom profiles (e.g., anxiety, antisocial behavior, obsessive compulsive, and psychotic-like symptoms) remains to be explored.
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The pathway described here is entirely consistent with current BSP guidance7 on the use of the BPE, that is, its prosecution and interpretation has not changed.
Taken together, these data allow us to propose a model by which filopodia formation and stabilization via an integrin/Src/L-type calcium channel/calpain pathway, described here, contributes to directional cell motility and cancer cell invasion (Fig. 8c). Figure 8: Filopodia stabilization directs cell migration.
On the other hand, and of particular note, the p53-RASSF1A pathway described here may attenuate cell damage by silencing the RASSF1A tumor suppressor.
In line with the TEF-mediated pathway described here, both p53 and miRs have been involved in cell shape and cytoskeleton remodeling [8], [27], [28].
While similarities exist between phagocytosis and macropinocytosis in mammalian cells [53] and molecules such as actin and Cdc42 are common to macropinocytosis and Arf1-mediated pinocytosis, the fluid phase pathway described here in Drosophila appears to be unstimulated and does not depend on Rac1 activity.
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