A better understanding of tumor biology and identifying pathways critical for tumorigenesis can provide potential strategies for therapeutic intervention.
It is possible that the mechanism of anti-leukemic activity of DHODH inhibition more closely resembles that of other cancer therapies, like the BCL-2 inhibitor Venetoclax, that induce differentiation by targeting pathways critical for AML cell survival.
The identification of new signaling pathways critical for cardiac morphogenesis will contribute to our understanding of congenital heart disease (CHD), which remains a leading cause of mortality in newborn children worldwide.
We have developed a portfolio of antibodies that target biologic pathways critical for survival of tumor-initiating cells, with the goal being to stop those cells from replicating.
As it relates to lens biology, we are investigating the cytoskeletal signaling pathways critical for lens development and function.
MiRNAs are recognized as critical links in cellular pathways and carcinogenesis, regulating expression of genes in a wide range of pathways critical for cancer development and progression.
Our bioinformatics analyses suggest that miR-130a may be involved in many pathways critical for neurodevelopment and associated with pathogenesis of neurodevelopmental diseases (Table 1).
A summary is provided of recent studies examining the electrophysiological properties of CCK cells and newly discovered proteins that act as releasing factors for CCK, which mediate feedback pathways critical for regulated secretion in the intact organism.
GLN given 1 h postsepsis led to inhibition of lung tissue NF-kappaB activation (P < 0.001 vs. SP), attenuated degradation of IKBalpha, and inhibited phosphorylation of p38 MAPK, and ERK, pathways critical for cytokine release.
We previously conducted a human-mouse comparative genomics study on pathways critical for ESC self-renewal and differentiation [11].
This model of JAK2 V617F-induced polycythemia can be used to investigate signaling pathways critical for disease pathogenesis.
