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Dysregulation of metabolic pathways contributes to many diseases, so a detailed understanding of human metabolism has significant therapeutic implications.
The natural coordination among different metabolic pathways contributes to the complexity of metabolic modification, which hampers the development of biorefineries.
Growing evidence suggests that cross-talk between ER and growth factor receptor pathways contributes to the development of this resistance.
Detailed data and modeling of cyclohexane flames establish that a mixture of pathways contributes to benzene formation and that this mixture changes with stoichiometry.
Because activation of these pathways modulates cell survival and chemoresistance, it is conceivable that activation of these pathways contributes to TRAIL resistance.
We therefore postulated that LRP-1-dependent control of both ERK and JNK pathways contributes to modulate the cell-matrix interaction to support invasiveness.
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Table 1 Involvement of sirtuins in the pathways contributing to premature aging when dysregulated Pathways contributing to premature aging SIRT1 SIRT2 SIRT3 SIRT4 SIRT5 SIRT6 SIRT7 Cellular/replicative senescence √ ?
Both pathways contribute to the overall antiviral responses of the host.
At field sites with varying redox conditions, different redox-specific microbial degradation pathways contribute to total contaminant degradation.
Evidence suggests that Bax-dependent initiation and activation of intrinsic apoptotic pathways contribute to ischemic brain injury.
Numerous lines of evidence point to diversified pathways contributing to the control of both traits, and this control may involve some overlap of several pathways.
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CEO of Professional Science Editing for Scientists @ prosciediting.com