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Individualizing cancer therapy for molecular targeted inhibitors requires a new class of molecular profiling technology that can map the functional state of the cancer cell signal pathways containing the drug targets.
The pathways containing the highest numbers of affected genes are listed.
Merging and displaying separate pathways containing the same events is a unique feature.
Then we re-ranked the pathways containing the top 10% genes again.
Among the biological pathways containing the differentially expressed genes, we have identified those involved in mitochondrial dysfunction and oxidative phosphorylation as being the most consistently affected and modulated.
Finally, the Over-represented Pathway Summary merges the information in the previous tables to identify KEGG metabolic pathways containing the proteins and metabolites and ranks them by the highest number of hits per pathway.
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The KEGG pathways contain the genes assigned to these pathways.
The categories of plant hormone signal transduction and metabolic pathways contained the most targets, at 14.93%.
While the depleted pathways contain the genes that are not affected by the disease, the enriched pathways are significantly altered.
Interestingly, metabolic pathways contain the most abundant DEGs whereby most of the genes were down-regulated after the four challenges.
The results show that all the orthologous genes concerning the VEGF node in the HIF pathways contain the important TFBS for V$HIF_STKR_2005.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com