Sentence examples similar to pathways center from inspiring English sources

Around half the phosphatases identified in our screen fitted the kinase pathways centered on the Akt pathway.

Also, HGF/Met signaling may operate in nuclei of aggressive mammary cancer cells triggering still elusive transduction pathways, centered on Src nuclear activity, and influencing invasive metastatic phenotype.

Similarly, pathways centering on the cellular morphology-controlling small GTPases, RAC1 and/or RHOA, involving multiple palmitoylated proteins were identified (see Additional file 1: Table S4).

These genes were validated using qPCR and shown through pathway analysis to be associated with signaling pathways centered around p53 and GADD45A, consistent with a DNA damage response (data not shown).

It is likely that activation of the pathways centered on these counter-regulatory circuits is more swift and crucial in the context of an ischemia and reperfusion (I/R) injury, often referred to as "inflammation from within" (8).

Autophagy is initiated by signaling pathways centered around ULK1 (unc-51 like autophagy activating kinase 1) and ULK2, as well as the BECN1/Beclin 1-phosphatidylinositolinositol 3-kinase, catalytic subunit type 3) complex.

Robert Mahley (The J. David Gladstone Institutes) highlighted druggable pathways centered on the potential toxic gain of function of the ApoE4 protein, including increasing the mitochondrial protein cyclooxygenase-1 that appears to be decreased by proteolytic fragments of the ApoE4 protein.

The second pathway centers on land, with the human activity model making decisions on land use change based on natural ecosystem productivity and crop yield.

In this paper, we explored how ZnO nanoparticles cross-interact with a critical tumor suppressive pathway centered around p53, which is one of the most important known tumor suppressors that protects cells from developing cancer phenotypes through its control over major pathways like apoptosis, senescence and cell cycle progression.

Finally, the third pathway centers on water, with the Earth system model computing basin-wide geophysical water resources and the irrigation demand from crops, and the human system model making economically based decisions on water availability for irrigation, with competition from municipal and energy use.

Chung showed that astrocytes surrounded and ingested functioning synapses via a chemical pathway centered on a pair of proteins coded by its Pac-man genes.