Sentence examples for pathways can enhance from inspiring English sources

Mutations in, or dysfunction of, protein kinase signaling pathways that normally respond to DNA damage, for example, play critical roles in tumor development and progression, while intentional targeting of these pathways can enhance the ability of commonly used DNA damaging chemotherapy and radiation to cure cancer.

Therefore, it will be of interest to determine whether the alternation of metabolic pathways can enhance NK cell expansion without exhaustion.

Growth factor pathways can enhance ERα phosphorylation, transcriptional activity and cell growth in the absence of ERα ligand.

Further work should make it possible to understand how further exploitation of these pathways can enhance the induction of death in such tumour cells.

We suggest that such "anticipatory" phenotypes can be easily evolved by a single point mutation in a key signaling protein, the Ras2 small GTPase, and we propose a molecular model describing how specific ras2 alleles, and not null ras2 mutants, or mutations in other components of the Ras/cAMP pathway, can enhance the "predictive ability" of cells for future lethal stressors.

Therefore, the death receptor pathway can enhance the mitochondria-mediated pathway through multiple mechanisms.

An important future goal will be to address the role of EFA6 family members in mammalian axon regeneration, and whether manipulation of this MT regulatory pathway can enhance regeneration in therapeutic settings.

Activation of Nrf2 pathway can enhance the expression of detoxifying enzymes and antioxidants [ 15, 17] and attenuate hepatic fibrosis [ 18], nonalcoholic steatohepatitis [ 20], NAFLD [ 28], and drug-induced liver injury [ 21].

Pyk2 (Fand) and PKC, the important proteins in PLC/PKC/Pyk2/Src signaling pathway, can enhance NMDA receptor function in hippocampal neurons [ 55], and NMDA receptor may lead to Ca2+ internal flow, resulting in cerebral ischemic reperfusion [ 56].

One concern is that in the EET pathway can enhance acute hypoxic pulmonary artery vasoconstriction in mice isolated lungs, and thus possibly contribute to the development of pulmonary hypertension, but chronic treatment with sEH inhibition for 4 months did not affect muscularization of the pulmonary vasculature and exercise tolerance.

During the course of my medical training, my academic interests have expanded beyond care of the professional voice, to developing pathways that can enhance communication and quality of life for patients with no voice at all.