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It has been previously described that the effect of cancer signalling pathways can change due to the mutation or loss of oncogenes outside the main signalling pathway.
In the second scenario, an external stimulation that affects signalling pathways can change the gene expression state, thus triggering a state transition between attractor states in a multistable system.
With the first discoveries of regulation of CBC function, it is an exciting possibility that CBC is a complex through which cellular signalling pathways can change the gene expression landscape and cellular physiology.
Although it is still uncertain whether metabolic remodeling is a cause or consequence of cellular reprogramming, these studies clearly indicate that metabolic pathways can change depending on cellular states.
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If an environmental stress is strong enough to overcome this robustness, the developmental pathway can change through the expression of a cryptic genetic variant.
This result seems to support our conjecture that in different experimental conditions the degree of connection among pathway nodes can change.
In fact, changes in Ca2+ buffers or efflux pathways can alter matrix Ca2+, and changes in pH or other divalents can alter indicator fluorescence, without reflecting a true difference in uniporter activity.
By practicing "desensitization" a person can change the pathways in their brain that react fearfully to the things that scare them.
In vitro, under the action of some inducing factors, the expressing of some key genes in the signaling pathway related to stem cell differentiation can change.
Situations can change, people can change".
Apparent genomic heterogeneity, "noise", arises because there are multiple ways a pathway can be changed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com