Sentence examples for pathways can alter from inspiring English sources

Laboratory studies provide evidence that inhibitory checkpoint pathways can alter metabolic reprogramming of T cells [15, 230].

It has previously been suggested that modulation of cell stress pathways can alter the response of neurons to neurodegenerative stimuli [13] [14].

In fact, changes in Ca2+ buffers or efflux pathways can alter matrix Ca2+, and changes in pH or other divalents can alter indicator fluorescence, without reflecting a true difference in uniporter activity.

Since we consider a simple model each parameter value represents a wider range of processes and our observation thus implies that both changes in protein concentration as well as cross-talk between signaling pathways can alter the qualitative response to a TGF- β stimulus.

These results suggest that splenic nerve-derived catecholamines regulate the egress of splenic monocytes during infection and that altering this pathway can alter survival during septic peritonitis in mice.

The primary RNA silencing pathway can alter the viral growth pattern substantially: it can slow down and decrease viral growth, cause oscillations, or can result in complete virus clearance.

Recently, several studies have demonstrated that EGFR is a target of a number of miRNAs, and vice versa a mutation or activity of the EGFR signaling pathway can alter the expressions of miRNAs in lung cancer (Table 1) [ 14– 17].

Others have shown Her2 activation to be associated with relocalization to the cytoplasm rather than nuclear accumulation of Jab1 [ 46] and that activation of the Her2-ras-MAP kinase pathway can alter Jab1 and stimulate downregulation of p27 [ 47].

Our results indicate that oscillatory behavior in the ERK pathway can alter homeostatic gene regulation patterns and that the cellular response to perturbation may manifest differently in oscillating vs nonoscillating cells.

The notion that the insulin/IGF-1 signaling pathway can alter the activity of the DA pathway in C. elegans is compatible with the emerging idea that, in the mammalian brain, hormonal signals involved in energy balance, including insulin, can affect the DA reward pathway to modulate feeding behavior (Figlewicz et al. 2007).

These data highlight the interaction between the different Ca2+ efflux pathways and their location, showing that changes in the location of a single pathway can alter the activity of the other Ca2+ flux pathways, as well as Ca2+ concentrations in subcellular spaces and the electrophysiology of the cell.