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This transport of amino acids does not involve enzymes in metabolic pathways but rather transport proteins embedded in cellular or intracellular organelle membranes.
FGF-2-induced endothelial migration in vitro is not dependent on PKC/PLA2 or pertussis-toxin sensitive G-protein pathways but rather requires activation of a phosphoinositol (3 -kinase-like enzyme and/or arachidonic acid release with subsequent liberation of lipoxygenase products.
In the bladder smooth muscle cell, the fluidization response to transient stretch occurs not through signaling pathways, but rather through release of increased tensile forces that drive acute disassociation of actin.
It should be mentioned that overexpression of the transcription factors in Arabidopsis plants might induce tolerance observations not related to activation of specific pathways but rather indirect or pleiotropic effects.
This cascade is not involved in the phytohormone-related signaling pathways, but rather directly impacts transcription factors for defense responses.
The top hits for nearby profiles were not for the BMP/TGF-Beta signaling pathways but rather for telomere maintenance (WRN), Notch (NOTCH2), and MAPK signaling (RAF1).
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NADPH oxidases act not as isolated elements downstream of a particular pathway, but rather may amplify multiple receptor tyrosine kinase-mediated processes by inhibiting protein tyrosine phosphatases.
Recent advances demonstrate that BER does not operate as an isolated pathway but rather dynamically interacts with components of other DNA repair pathways to modulate and coordinate BER functions.
Altogether, these results demonstrate that rasl11b does not act upstream of Smad2 and confirm that Rasl11b does not influence the activation level of the Nodal pathway but rather acts on mesendoderm formation in a Nodal-independent way.
It would therefore not be appropriate to consider the link between sterol biosynthesis and vascular differentiation as a linear pathway, but rather as a network of interdependent components, the relationships between which we are beginning to unravel.
This effect is probably not due to a single common pathway, but rather to specific mechanisms in different tissues.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com