Sentence examples for pathways at once from inspiring English sources

Between the two pathways, there will be more observed synthetic-lethality interactions: if corresponding components are deleted or suppressed in both pathways at once, the fault-tolerance of the system is defeated and the strain dies.

In theory, such an approach may abrogate or delay resistance by disrupting multiple pathways at once.

Furthermore, it achieves a new level of complexity by considering multiple pathways at once in a comprehensive manner.

Static modeling of dynamic interactions aggregates several different pathways at once, which leads to missing key factors that are only active at specific times during response (Ernst et al., 2007).

In contrast to the traditional single molecule-single target approach, being able to target two or more pathways at once or a few players in the same pathway would be a more effective therapy for the treatment of cancer.

Many downstream signaling effectors involved in malignancy are regulated by both Stat3 and NF-κB, such that targeting both of these signaling pathways at once by combining ATRA + AUR, may produce a synergistic tumor suppressive effect.

Combination therapy might promote synergistic effects leading to low drug dosage, as well as suppresses resistance to therapy if multiple cell survival pathways are targeted at once though there are chances of higher toxicity.

Maps or diagrams of signaling pathways help summarize many interactions at once.

We show unambiguously that ADP release is the rate limiting step of the reaction pathway and that KanA is at once a substrate and a powerful inhibitor because it interacts with the intermediate E·ADP as well as with the apoenzyme.

Consequently, the GIV●G protein interface serves as a central hub allowing for control over several pathways within the pathologic signaling network, all at once.

To overcome these problems, MapMan [ 2] introduced an ontology which removes redundancies, and displays metabolic maps including many processes at once, thus immediately highlighting important pathways.