Sentence examples for pathways as novel from inspiring English sources
71 We also identified 76 proteins in 49 host –pathogen common metabolic pathways as novel targets.
These results might establish the basis for using p38 MAPK pathways as novel molecular targets for the treatment of COPD.
We investigated the relevance of the mammalian target of rapamycin (mTOR)/AKT and hypoxic pathways as novel immunohistochemical markers of malignancy.
Importantly, we found genes associated with oncogenic Ras pathways, as well as with TNF and IFN response pathways, as novel gene sets in CD24−/low/CD44+ populations.
Studies are therefore warranted to develop TTN-receptor ligands to assess the relevance of TTN-operated pathways as novel targets for the pharmacological modulation of PMNs during the inflammatory process.
The significant pathways identified once again included known regulators of cellular cholesterol homeostasis such as lipid metabolism, regulation of metabolism and Ras pathways as well as novel pathways such as Gap junction (Figure 3D), B-cell receptor and the Slit-Robo signaling pathways (Table 3).
Targeted searches using these annotations identified the majority of genes associated with essential metabolic pathways and conserved signaling pathways, as well as novel candidate genes for stress-related processes.
Functional cross-talk between the receptor signaling pathways as well as novel pharmacological and/or functional properties will provide evidence for the mechanism by which receptor-receptor-interactions modulate cellular activity [ 218].
We also utilized differentially expressed microRNAs to identify novel pathways as well as validate mechanisms previously implicated with Dupuytren's disease.
GoSynthetic allows further planning of such artificial design experiments including search for drug targets, novel pathways as well as modify regulatory input critical for certain processes.
The hierarchical approach suggested potential mechanisms involved in mediating the cytotoxic and cytoprotective pathways, as well as identified novel targets, such as NADH dehydrogenases, aldehyde dehydrogenases 1A1 (andH1A1) and endothelial membrane protein 3 (EMP3) as modulator of the toxic phenotypes.
