Sentence examples for pathways as demonstrated from inspiring English sources

Furthermore, the overlap of EGF and IGF-2 pathways, as demonstrated by merging both networks into a single pathway, could enable IGF-2 to take over the functional role of EGF and thus render the tumor cell independent of EGF signaling.

MeCP2 protein contains different domains that may be targeted by these pathways as demonstrated by a bioinformatic analysis (Motif Scan) performed in our laboratory.

The contigs were mapped to 140 KEGG pathways, as demonstrated in Additional file 4. Figure  6 summarizes the top 20 represented biological pathways including at least 200 contigs.

Fibroblast growth factor-2 activated the Erk1/2-MAPK and PI3K-Akt signalling pathways as demonstrated by the increased phosphorylation of Erk1/2 and Akt.

As this figure shows, the concordance between permutation of rows and columns appears generally high, at least for the subset of 20 pathways, as demonstrated by a correlation of 0.84.

Our study suggest that C. sativum root extract inhibited MCF-7 breast cancer cells by the death receptor and mitochondrial apoptotic pathways as demonstrated by significantly increased caspases-3, -8 and -9 activities compared to the control.

48 Attention needs to be put on the dynamics of health systems in different contexts and identify possible pathways to achieve universal coverage, as demonstrated by the diversity and pluralism of service delivery models existing on every continent (eg, the need for private and public sectors, formal and informal sectors).

Indeed irradiation activated the Notch pathway, as demonstrated by the expression of the Notch target genes Hey1, and its inhibition by the γ-secretase inhibition GSI (Figure S5b).

The p53 stress response pathway functions as a critical tumor suppressor pathway, as demonstrated by the observation that the p53 gene is one of the most commonly mutated genes in human tumors [1].

When Olig2, a differentiation-inducing signal, was overexpressed, this led to lineage-specific differentiation of neural stem cells and downregulation of Wnt pathway (i.e., self-renewal pathway) as demonstrated by F3.Olig2.

An alternative model would be that miR-155 attenuates the inflammatory intracellular pathway, as demonstrated recently [34] by directly targeting adaptor molecules of the TLR/IL1 signaling cascade such as MAP3K7IP7/TAB2.