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Once variation from IL23R is removed, these two pathways are no longer significant in any of the datasets.
The impact on the J and NJ data is more dramatic; all IL23R containing pathways are no longer significant.
Once membrane space permits complete metabolism of glucose influx at ~50% protein-occupied surface area, fermentation pathways are no longer heavily employed which improves metabolic efficiency, hence the drop in in glucose uptake and increase oxygen uptake.
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However, the "apoptosis" and "oxidative phosphorylation" pathways were no longer significantly enriched, with either of the scaled datasets.
For example CheW2 and CheW3, which are present in the same pathway, are no more similar to each other than to the other CheW homologues (Additional file 13).
The rejection of this null hypothesis (which basically says genes in a pathway are no different from random ones) can only imply an alternate hypothesis that says genes in a pathway do behave differently from a random set of genes.
Following a review, the pathway is no longer used.
The reason for this discrepancy is unclear, but these results are supported by our in vitro findings showing that at the highest concentrations of PGPC, the Nrf2/ARE pathway was no longer stimulated or even reduced.
However, changes in this pathway were no longer significant on days 8 and 14 as compared to control levels.
Protein trafficking through the secretory pathway is no less complicated than endocytosis and occurs in a highly regulated manner 11.
Of the nine differentially expressed transmembrane transport pathway genes, eight were up-regulated on d 2. By d 7, this pathway was no longer significantly over-represented.
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