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The lumped biochemical reactions in the metabolic pathways are generated by stoichiometrically coupling several sequential elementary reactions.
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Does he perhaps think that these pathways were generated by different mechanisms?
Pathways were generated by placing only statistically significantly differentially expressed genes with a minimum 1.8-fold difference between groups into Ingenuity Pathways Analysis (Ingenuity Systems®, Redwood City, CA).
Electrons for the reduction pathway are generated by oxidation of molecular hydrogen, catalyzed by electron-bifurcating hydrogenases [ 16].
Extracellular beta-amyloid peptides secreted from this pathway are generated by beta-secretase processing of amyloid precursor protein [ 34].
Other unique sperm isozymes in this pathway are generated by alternative splicing, including hexokinase 1 variants (HK1_V1 and HK1_V2) [ 5- 7], ALDOA_V2 [ 4], and a pyruvate kinase muscle form isozyme (PK-S) [ 8].
In Figure 3, the model assumes that cancer tumors are generated by two pathways with pathway 1 as a k1-stage multi-stage model involving I l (l = 1,..., k1) cells and with pathway 2 as a k2-stage multi-stage model involving J r (r = 1,..., k2) cells.
According to the KO assignment, metabolic pathways were generated with tools supplied by KEGG [ 31].
They are generated by two pathways controlled by the enzyme systems cyclooxygenase and lipoxygenase, respectively.
We discuss this dissociation between high- and low-frequency oscillations in relation to proposals that lower-frequency oscillations are generated by feedback pathways within visual cortex [ 20, 21].
The representative pathways were generated using pathway analysis tool, by Fisher's Exact test and the C. reinhardtii KEGG database (http://www.genome.jp/).jp/
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