Sentence examples for pathways are frequently from inspiring English sources

In fungi, genes related to secondary metabolic pathways are frequently clustered together and show a modular organization within fungal genomes.

Bacterial genes whose enzymes are either assembled into complex multi-domain proteins or form biosynthetic pathways are frequently organized within large chromosomal clusters.

Zhang J, Mullighan CG, Harvey RC, Wu G, Chen X, Edmonson M et al. Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.

Among the MYC targets, those that were specifically overrepresented within the basal-like breast cancers, which include modulators of kynurenine, prostaglandin, and Wnt pathways, are frequently deregulated in human cancers60,61,62.

Phosphatidylinositide 3-kinase (PI3K) / mammalian target of rapamycin (mTOR) pathways are frequently activated in TNBC patient tumors at the genome, gene expression and protein levels, and mTOR inhibitors have been shown to inhibit growth in TNBC cell lines.

The phosphatidylinositol 3-kinase (PI3K /AKT/mammalian target of rapamycin (mTOR) and the RAF/mitogen-activated and extracellular signal-regulated kinase kinase (MEK /extracellular signal-regulated kinase (ERK) signaling pathways are frequently deregulated in cancer.

Nutritional modulation of metabolic pathways is frequently mediated by nuclear receptors that act as ligand-activated transcription factors [ 21].

Several oncogenes and tumor-suppressor genes that activate mTORC1, often through the phosphatidylinositol 3-kinase (PI3K /AKT pathway, are frequently dysregulated in cancer.

Defects in the MMR pathway are frequently found in hereditary nonpolyposis colorectal cancer.

Indeed, components of mTOR signaling pathway are frequently activated or over-expressed in CRC [ 10, 11].

Abnormalities of Wnt/β-catenin pathway are frequently involved in multiple malignancies [24].