Therefore, the glucosamine pathway was extended to N-acetylglucosamine by over-expressing a heterologous glucosamine-6-P N-acetyltransferase.
Subsequently, the pathway was extended to (S,S -2,3-butanediol (S,S -2,3-butanediolciently linking two metabolic pathwayS,S -2,3-butanediollysis.
The carotenoid pathway was extended further by including a bacterial ketolase gene able to form astaxanthin, a high value carotenoid which is not a typical plant carotenoid.
This pathway was extended with the side chain degradation of rings C and D (Additional file 3) and several genes involved in the pathway were added based on additional literature [ 21- 28].
The emerging systems-biology approach to studying the functional synergy between cardiac miRNAs in the context of cell death pathways should be extended to incorporate more extended network of signaling pathways, including ROS signaling.
Folded winglets are extended.
Therefore, the pathways can be extended with an enormous amount of information and provide a foundation for initial structural modeling approaches.
In order to test the hypothesis that intronic miRNAs might act as regulators even in the global functional context of a negative feedback loop circuitry, the KEGG pathway analysis was extended to identify targets within the respective biomolecular pathway.
