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Further degradation pathways are difficult to anticipate.
Therefore, these pathways are difficult to evolve.
In addition, "Although these high-dimensional pathways are difficult for us to visualize, they are persistent across replicates of a given scenario.
True clinical trials, which might help disentangle and clarify specific causal pathways, are difficult to carry out, as Meléndez points out.
The data source for the analysis in this chapter was cross-sectional in nature, and as a result causal pathways are difficult to infer.
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We've been running this experiment for four years and even in the simple systems, unpicking the pathways is difficult.
Each of these research pathways is difficult and costly, and will require billions of dollars in investment.
Second, maintaining static signals throughout cortico-cortical pathways is difficult.
Disentangling exposure pathways was difficult because agricultural populations are concurrently exposed to pesticides via multiple pathways.
However, the precise nature of the corresponding pathways is difficult to predict because, as we have seen in the canonical pathways, the order of steps can be arranged in various ways.
Determining whether solutes cross venular endothelium by inter-endothelial cell or transcellular (by VVOs) pathways is difficult because of the tortuosity of inter-endothelial cell borders and the proximity of VVOs to these borders.
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