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Edges in signaling pathways are derived from direct interactions of the corresponding signaling proteins.
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We present here a comprehensive definition of therapeutic exergames from which a methodology to create safe exergames for real therapy pathways is derived.
Although a small portion of the pathways were derived from KEGG, most components of the networks were constructed from information collected from the literature.
A biochemical pathway database containing more than 300 predicted metabolite pathways was derived from these EST sequences.
All listed or reconstructed cellular pathways were derived from the expert annotated database that is provided by the Ingenuity Knowledge Base.
Most of our knowledge on cell responses to insoluble extracellular triggers and the mapping of intracellular signalling pathways is derived primarily from studies in plastic-based cell culture.
In addition, a topic set entitled "Pathways" was derived using the pathway descriptions from BioCarta [ 29] with some additional curation and testing (see Additional File 1 for methods and Additional File 2 for list of pathways).
The combined data for signaling pathways were derived from three pathway databases, including KEGG: Kyoto Encyclopedia of Genes and Genomes (Kanehisa et al., 2004), NCI PID: Pathway Interaction Database (Schaefer et al., 2009) and BioCarta (Schaefer et al., 2009).
The specificity of these pathways is derived from phosphorylation of Raf1 on adjacent sites; VEGF-dependent phosphorylation is dependent on p21-activated kinase 1 (Pand), and FGF-dependent phosphorylation is dependent on Src kinase.
Most abundant glycero phospho lipids, generated in the de novo pathway are derived from phosphatidic acid (PA -derived diacylglycerol (DAG).
Therefore, we conclude that the genes involved in the TGF- β signalling pathway are derived from human cells within the tumours.
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