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Thus, although it is possible that some genes within these pathways are changed due to the effect of PIO, the effect does not appear either statistically reliable or pathway-selective.
Up-regulation of signaling genes and down-regulation of transcriptional regulators at diapause initiation indicate that signaling pathways are changed, global transcription levels are down-regulated, and diapause does require a unique gene expression regulatory mechanism.
When energy deprivation occurs in plant cells, transcript levels of genes involved in protein synthesis, cell wall biosynthesis, sucrose metabolism, transporters, chromosome and histone modification, and phytohormone signal pathways are changed [ 45].
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A number of transcripts encoding proteins regulating intracellular trafficking of secretory pathways were changed, with a predominant increase in transcription of ER/Golgi-related transcripts.
We found that 88 pathways were changed by DR, and 105 pathways by Rapa (Fig. 4A).
Six pathways were changed with at least three downregulated genes (Table 3).
A most remarkable finding is that many pathways were changed at 3.5 months, more than 1 year prior to the first neuropathological signs.
The MapMan analysis indicated that some metabolic pathways were changed by allelic alterations at both loci, GS3 and qGL3 (Fig. 4a).
The two-year-long experiment revealed that plant genes involved in primary and secondary metabolic pathways were changed in response to infection and that these changes might support phytoplasma nutrition.
The patient is a non-smoker, not noted to have significant intake of caffeine and no other medications known to interact with the clozapine metabolic pathways were changed during the period.
To determine whether similar pathways were changed in response to a GNRH agonist in vivo, we used an antibody array with 117 pairs of antibodies (Supplementary Table 1) to detect both the phosphorylated and non-phosphorylated forms of selected proteins in SCL60 xenografts treated with Triptorelin.
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