Sentence examples for pathways are central from inspiring English sources

Ca2 +-dependent signaling pathways are central regulators of differentiated vascular smooth muscle (VSM) contractile function.

The MAP kinase (Ras/MEK/ERK) and PI3K/Akt/mTOR oncogenic signaling pathways are central regulators of KRAS-mediated transformation.

To provide perspective on the implications of the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) on intravitreal biologic agents in uveitis and retinal diseases in which ocular inflammatory pathways are central to their pathogenesis.

However, since phytic acid and its synthetic pathways are central to a number of metabolic, developmental and signaling pathways important to plant function and productivity, low-phytate can translate into low-yield or stress susceptibility.

These pathways are central to vision and other photo-reactive phenotypes in most extant animals.

These pathways are central to metabolic control and the patterns we observe in two independent data-sets (male and female) reflect this.

Cross-talk of intracellular signaling pathways is central to many neuroendocrine control systems [3], [4].

These pathways being central to the metabolic function of the liver, this suggests that A20 overexpression not only enhances the liver's synthetic and metabolic functions, but also preserves these functions during the proliferative phase of liver regeneration, when they are usually down-regulated as a result of energy shunting.

In a recent report, Toxicity Testing in the 21st Century, the National Research Council Committee on Toxicity Testing and Assessment of Environmental Agents (2007) proposed that improved scientific understanding of toxicity pathways was central to the expanded use of predictive, pathway-based bioassays in risk assessment.

For example, insulin signaling regulates invertebrate and vertebrate lifespan, and drugs that target this pathway are central diabetes therapies [7], [13], [57].

Several animal models and numerous in vitro studies have demonstrated that the p53 pathway is central to the ribosomopathy phenotype.