Your English writing platform
Discover LudwigSuggestions(2)
Exact(3)
Both pathways and samples were clustered.
Pathways and samples were clustered with different metrics: in particular, Euclidean distance, Pearson's correlation and Manhattan distance were used.
Specifically, we used standard hierarchical clustering and clustering with support trees [34]: in the latter case pathways and samples were bootstrapped over 100 and 1000 iterations.
Similar(57)
This is illustrated with an example including 3 hypothetical pathways and 4 samples, which belong to two clinical classes, A and B. For a given sample, si, a Li,k value is calculated with respect to each pathway, MPk.
Our approach and GSEA [9] differ with regard to the following aspects: pathway scoring, differential pathway detection, and sample-specific information representation for classification.
All individuals of each dataset were projected to biological pathways, and each sample's Mahalanobis distance from a pooled centroid was calculated to compare the number of case and control outliers for each pathway.
Table 2 shows the estimated type I error rates of the two proposed PEM D and UD under different pathway lengths and sample sizes.
We then performed hierarchical clustering of the samples based on each sample's probability of activation of Src, Ras and PI3K pathways, and observed that samples were classified into seven clusters with distinct pathway activation patterns.
In the present work, we designed our own gene array containing genes involved in various signaling transduction pathways and analyzed placental samples from patients with preeclampsia and controls.
At the end of this procedure, each sample will be associated with n L-values, and each pathway will assigned to m L-values, with n and m representing the total number of pathways and number of samples respectively.
To achieve this objective, reads are usually mapped to the known genes or pathways, and then the samples are compared using the active genes or pathway.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com