Sentence examples for pathways and prevent from inspiring English sources

We also discuss the pharmacological approaches that interfere with the mitogenic pathways and prevent mature neurons from attempting cell cycle re-entry, protecting them from cell death.

It will provide an opportunity to develop therapy targeting such genes and pathways and prevent overt metastases.

Hirano et al. [ 26] reported the usefulness of preoperative coil embolization of the common hepatic artery to enlarge the collateral pathways and prevent ischemia-related complications in patients who underwent distal pancreatectomy with en bloc celiac axis resection.

IAP proteins comprise a family of antiapoptotic proteins that promote prosurvival signaling pathways and prevent the activation of the effector phase of apoptosis by interfering with the activation of caspases [ 29].

Thus, NMD appears to have a significant role in controlling the expression of aberrant proteins in these pathways, and prevents their deleterious effects.

Tumor suppressor gene p53 is the guardian of all genes and regulates the various cellular and molecular pathways and prevents cancer formation.

Indeed, we show that lenalidomide blocks the activation of STAT3 and SMAD2/3 signaling pathways and prevents the suppression of NK cell activation in vitro.

In future studies, two or more of our predicted cancer drug targets, as well as existing drug targets, could be exploited using combinatorial drug therapy by blocking different signaling pathways and preventing cross-talk between pathways in cancer.

The endogenous cardioprotective phenomenon of ischaemic conditioning, in which the heart is protected against MI by subjecting it to brief cycles of ischaemia and reperfusion, mediates its cardioprotective effect by recruiting many signalling pathways and preventing MPTP opening (Hausenloy et al., 2002, 2009a).

Specifically, through a sequestration mechanism that is yet to be characterized at the molecular level, E proteins are locked into ectopic SCL core complexes that act by repressing apoptotic pathways and preventing the normal T cell transcriptional program (Herblot et al., 2000; Palii et al., 2011; Sanda et al., 2012).

APC deficiency and beta-catenin mutations upregulate the WNT/beta-catenin pathway and prevent beta-catenin degradation.