Gerecht's CAREER project is focused on an interdisciplinary investigation of functional interactions between hypoxic pathways and matrix-driven cues that are essential for vascular morphogenesis and network assembly.
The study revealed complex changes in estrogen-responsive pathways, proliferation and matrix remodelling, which cannot be simply summarized by the ER status of the tumours or completely recapitulated in cell line studies.
Count matrices generated for pathway-level comparisons consisted of 353 pathways and a matrix of KO terms comprised of 4,399 KO terms generated for gene-level comparisons.
Baroni, T. et al. Human cleft lip and palate fibroblasts and normal nicotine-treated fibroblasts show altered in vitro expressions of genes related to molecular signaling pathways and extracellular matrix metabolism.
In this study, we characterized the cardiovascular progenitor cell (CPC) niche in developing human and mouse hearts, identifying signaling pathways and extracellular matrix (ECM) proteins that are crucial for CPC maintenance and expansion.
The HOXA11 antisense RNA (HOXA11-AS) was associated with collagen formation pathways and extracellular matrix organization pathways.
Additionally, self-renewal pathways such as the Wnt and hedgehog signalling pathways, cancer pathways, and extracellular matrix (ECM -receptor intECM -receptorways are sinteractiony associated with the pathways lung CSCs.
Functional gene set analysis of 3SEQ data from frozen tissue and FFPET revealed two key sets of pathways (Wnt signalling-related pathways, and extracellular matrix-related pathways) to be enriched in DTF.
Some down-regulated genes were found to belong to KEGG pathways (Table 6), e.g. the ribosome, oxidative phosphorylation and ATP synthesis, calcium signaling pathway and extracellular matrix (ECM /receptor interaction.
A different functional profile is observed 30 DPP depicted by the top enriched pathways (adjusted P < 0.1) at this time (Table 2), which are indicative of proliferation and repair such as pathways in cancer, focal adhesion, wingless type (wnt) signalling pathway and extracellular matrix (ECM -receptor intECM -receptor
