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Short-immunomers show strong activation of NF-κB and stress-activated signaling pathways and induce cytokines in J774 cell cultures.
Moreover, our results demonstrate that BCG-PSN can activate TLR signaling pathways and induce Th1-type cytokines secretion.
Therefore, increased alpha ketoglutarate levels may also activate mTOR pathways and induce cellular hyperproliferation.
Some POPs can disrupt multiple endocrine pathways and induce a wide range of toxic responses [ 1].
Oncogenic Ras and Raf activate MAPK and mTOR pathways and induce p21 and p16, causing senescence [ 9, 24- 27].
These reactive species are involved in many important cellular signaling pathways and induce the expression of physiologically necessary genes [ 10].
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RAGE-ligand interaction activates intracellular pathways and induces pro-inflammatory cytokines, proteases, and oxidative stress [17].
We proposed that Cd-elevated [Ca2+]i activates MAPK/mTOR pathways and induces neuronal apoptosis through CaM.
Conversely, incubation of cells with yeast before infection inhibited activation of ERK1/2 and JNK pathways and, induced a decrease in p38 phosphorylation and IκB.
The Polyoma Middle T Antigen (PyV MT) oncogene activates PI3K and Shc/MAPK dependent pathways, and induces c-Jun phosphorylation (via JNK activation) and transcriptional activity [2].
The upregulation of TNFRSF21 activated NF- κB and APK8/JNK pathways and induced apoptosis.
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