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In this subset, we analyzed 365 KEGG DISEASE proteins located in the NCI PID signaling pathways and identified 123 (33.7%) proteins as microRNA targets.
This research demonstrated crosstalk between MEK and PI3 kinase pathways, and identified a novel signaling link in the nucleus of stressed cells that connects Akt phosphorylated on Ser473 with dually phosphorylated ERK1/2 [9].
We also conducted multivariate analysis in canonical pathways and identified a consistent signal in the downstream pathways targeted by Gleevec (P = 0.004 in Pfizer PP = 0.028 in ADNI and P = 0.04 in GenADA).
To analyze the role that miRNAs play in the regulatory networks, we assigned putative miRNA targets into KEGG pathways, and identified 14 of them were significantly enriched (P<0.001, with Benjamini correction).
We then matched the unigenes to 187 pathways and identified 47 PUFA biosynthesis related genes.
We devised schemata showing 'typical' care pathways and identified over 100 patient management questions.
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This process also delineates hydrocarbon migration pathways and identifies structural and stratigraphic traps.
This work provides the first glimpse into the Dub interaction landscape, places previously unstudied Dubs within putative biological pathways, and identifies previously unknown interactions and protein complexes involved in this increasingly important arm of the ubiquitin-proteasome pathway.
These types of genomic studies will enhance our understanding of transcriptional networks and developmental pathways and identify novel targets genes important for vertebrate development.
Importantly, these techniques often uncover previously unanticipated pathways and identify of new targets for therapy.
We perform a narrative synthesis in order to map critical pathways and identify hypotheses for subsequent research.
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