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Timing-based mechanisms may underlie the assembly of the other sensory pathways and complex neural circuitry in the brain.
Mutated proteins do not function in isolation but rather through interacting within pathways and complex networks which propagate the disease causing effect.
The human brain is a myriad of interconnected pathways and complex dynamical interactions.
Multiple inhibitors blocked ERK activation, suggesting simultaneous use of multiple pathways and complex signaling web interactions.
The action of elevated cytokine-induced NO/cGMP pathways and complex interplay with CNP is unknown and requires further investigation.
In particular, heat shock triggers multiple signaling pathways and complex regulation of gene expression in cells and tissues.
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Our methodological improvements enable unbiased genome-wide clustering based on co-essentiality profiles; we recover pathways and complexes as diverse as MAPK/ERK, PI3K/ACT/mTOR, the ribosome, the peroxisome, regulators of the DNA damage response and chromatin remodeling.
The protein-protein interaction represents mutual relationship between the proteins and the mapping of such interactions can be predicted by high-throughput proteomic analysis or links based on protein components between pathways and complexes [10].
Most genes do not work in isolation but rather function together in pathways and complexes.
Such subgraphs can be used to link kinase specific substrates to pathways and complexes.
We nonetheless show here that these hit-rate based methods utilising biological pathways and complexes are powerful and precise.
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