Sentence examples for pathways and cause from inspiring English sources

All these mutations in HMCLs, which resemble extramedullary MMCs, affect BAFF-associated pathways and cause constitutive activation of NF-κB.

Even small-scale features such as bedding may influence the fluid pathways and cause local fluctuations in alteration intensity.

ATX/LPA stimulate the PI3-K, Akt, and ERK pathways and cause the activation of Rho and Rac [ 59].

Secondly, the type of surgery applied in these cases is generally more invasive, and could affect more input-output cerebellar pathways and cause post-surgery complications.

Further experiments will be required to determine how Salmonella genes, particularly SPI-2 genes, affect intracellular signalling pathways and cause increased replication of bacteria in HLA-B27 cells.

Other diseases that affect the glycolytic/glycogenolytic pathways and cause rhabdomyolysis include Tarui's disease (congenital phosphofruktokinase deficiency) and phosphoglycerate mutase deficiency [ 52].

In addition, we demonstrated that NDUFA4L2 is an HIF1alpha target in ccRCC and that NDUFA4L2 knockdown has a profound anti-proliferative effect, alters metabolic pathways, and causes major stress in cultured RCC cells.

ROS can cause oxidative stress, which in turn upregulates inflammatory pathways and causes mitochondrial damage.

BACKGROUND: Superoxide dismutase (SOD), an antioxidant acting against superoxide (oxygen radical, O2.-), it is released in inflammatory pathways and causes connective tissue breakdown.

Loss of E-cadherin promotes metastasis by inducing cancer cell disaggregation, activating specific downstream signal transduction pathways, and causing epithelial-mesenchymal transition (EMT), which facilitates metastasis.

However, excessive and sustained ROS levels may lead to cell growth arrest, senescence and cell death by activating alternative signalling pathways and causing fatal macromolecular damage (Martindale and Holbrook, 2002; Hussain et al, 2003).