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CD30 activates NF-κB via both canonical and non-canonical pathways and both ligand-dependently and -independently [ 11].
There is, however, crosstalk between the two pathways and both are responsible for increased ERK signalling [ 20, 24].
At all analyzed locations, cells coexpressed regulators of multiple signaling pathways and both AP and DV PCGs.
Apoptosis is mediated by two pathways, the extrinsic and the intrinsic pathways, and both have been described in cardiac myocytes.
H3K9 methylation, as discussed below, maintains germline silencing mechanisms initiated by RNA interference (RNAi) pathways, and both play essential roles in heritable modes of gene repression.
In addition, EP300 and NCOA2 take part on the AR and ER pathways and both, NCOA2 and FHL2 are AR co-regulators [ 43, 57, 58].
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The homolog of ZNRF3, RNF43, is induced and regulated in the Wnt pathway and both play similar functions to ubiquitinate and degrade Frizzled receptors (Koo et al., 2012).
Clinicians and sports medicine physicians play a key role in establishing both an accurate prognosis and a return to training and competition pathway, and both MR imaging and ultrasound are useful adjuncts to the clinical assessment.
Thus, features of oncogene-induced senescence in the αGSU.PTTG pituitary included induction of the p19/p53/p27 DNA damage pathway, and both p15 and p16 Cdk inhibitors [7], [40].
A novel Pax3/Pax7-involved pathway and both canonical and non-canonical Wnt pathways are involved in this activation.
The IGF-1 pathway highly interacts with the p53 pathway and both pathways constitutes important components involved in longevity [ 27- 29].
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