A synthetic biological approach, e.g., metabolic engineering of secondary metabolites, can be utilized to exploit the natural metabolic pathways against MDR microbes.
To uncover the pathways against which future therapies could be developed we undertook a meta-analysis of gene expression from five large microarray datasets relative to ER status.
Therefore, we examined the neuroprotective effects of adiponectin-activated pathways against FAS.
Many cells have developed intrinsic detoxifying pathways against accumulation of AGEs.
We then suggest a role for this effect in insulating pathways against crosstalk.
Pinocembrin has been shown to promote neurovascular inflammatory pathways against various types of A β toxicity [ 31, 32].
We titrated the FGF and TGFβ signalling pathways against one another, under conditions in which BMP signals were not limiting.
Thus, regulatory mechanisms similar to those described in this work might conceivably operate to stabilize other developmental pathways against temperature fluctuation.
To the best of our knowledge, this study is the first to provide evidence of anti-necroptotic pathways against hypoxic stress in colorectal cancer cells.
Validating the weighted enrichment methods has proved to be challenging because there is no ground truth to compare the enriched pathways against.
Canalization buffers developmental pathways against the tendency for both new allelic variants and environmentally-induced noise to generate suboptimal phenotypes, and thereby ensures the reliability of vital mechanisms such as cognition, glucose metabolism or immune response [ 4].
