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The biological and clinical data suggest that there are multiple bioactivation pathways accessible to nitrates and multiple sites of action, and also that the mediators of bioactivity include but are not limited to NO itself.
Epistasis can constrain the order of mutations and the pathways accessible to evolution, and hence it is of great importance in understanding the evolution of novel functions.
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Taken together, our results suggest that molecular recognition of fluorine, rather than simple inductive polarization and enolate stability, is involved in making the Cα deprotonation pathway accessible to the fluorinated substrate.
In all they found that for only a relatively small fraction (15%, 18/120) of possible pathways, all five steps increased resistance, suggesting that a relatively small number of possible pathways are accessible to natural selection.
The New Style stages differ in structure from that of Old Style, with some pathways only accessible to specific Robot Masters.
Complex 3 cleave pBR322 DNA via hydrolytic pathway and accessible to major groove of DNA.
In terms of plasticity the iterative role of Notch signalling means that the pathway is accessible to cells throughout the crypt to villus axis.
Current "Both, And" pathways are not accessible to all students.
These show all metabolic pathways accessible for the system.
Our findings help to address a longstanding problem associated with the study of mesodopaminergic pathways: preparations that are typically accessible to intracellular studies (such as cell and tissue culture models) invariably generate low-frequency autonomous spike activity while extracellular recordings of awake-behaving animals exhibit tonic and burst spike activity [ 21].
Unlike existing studies [22], [27], [36], these results imply a horizontal RNA transfer pathway between cells that is accessible to integration competent genomes, and therefore directly amenable to manipulation, Fig. 7. Two alternate, not mutually exclusive, hypotheses may explain what directs genomes to this pathway.
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