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The UK's 18 Week Pathway website provided information on the strategy's goals and actions, and data on current wait times [ 10].
The hypothesis was verified using a list of known E. coli pathways from the EcoCyc pathway website as the Gold Standard (Table 3).
Individuals who responded to these invitations were not required to have their personal physician order PGT; rather, these customers ordered their own testing from the Pathway website, in a similar fashion to 23andMe customers.
To evaluate whether gene pairs in the same pathway have lower GenoMesh dissimilarity scores than gene pairs from a random group of genes, a list of known E. coli pathways from the EcoCyc pathway website [ 43] was collected.
Pathway recruited new customers for enrollment in the PGen Study in two ways: a banner advertisement was placed on the Pathway website, and an email was sent to approximately 30,000 members of PatientsLikeMe, a health-based social networking site [ 49].
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Transport processes were added as suggested by the Malaria Parasite Metabolic Pathways website [ 26] as well as from literature [ 36- 50].
Classification was based on known function of proteins by reference to the BioCyc-MetaCyc: Encyclopedia of Metabolic Pathways website [ 28], by reference to the gene ontology (Go) database [ 29], and by searching related abstracts in PubMed [ 30].
The Pathway Commons website provides query and bulk download of these data.
A more thorough use case is available on the Pathway Distiller website including screen shots explaining Pathway Distiller's functionality.
This figure was created using the KEGG (Kanehisa and Goto, 2000 ) pathway database website (http://www.genome.jp/kegg/pathway.html ).html
The 20 genes identified as CACN-1 interactors were uploaded to the Pathway Palette website (Askenazi et al. 2010).
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