Sentence examples for pathway variants from inspiring English sources

Metabolic engineering requires functional genetic tools for easy and quick generation of multiple pathway variants.

Traditionally, analytical methods like chromatography and mass spectrometry have been used to evaluate pathway variants, but such techniques cannot be performed with high throughput.

Three F3H, three DFR, and two LAR genes originating from different plant species were selected and synthesized, to create 18 pathway variants to be screened in E. coli.

To further increase the FPP competitiveness of the lycopene synthesis pathway, we tried to enhance the catalytic performance of CrtE by directed evolution and created a series of pathway variants by varying the copy number of Crt genes.

Biosensors — genetically encoded components that actuate a cellular output in response to a change in metabolite concentration — are therefore a promising tool for rapid and high-throughput evaluation of candidate pathway variants.

We designed and constructed improved pathway variants by employing the RBS Library Calculator to efficiently search the 5-dimensional enzyme expression space and by performing 40 cycles of MAGE for site-directed genome mutagenesis.

This produced a list of genes that were differentially expressed for each DISC1 pathway variant.

Moreover and importantly, our analysis suggests that DISC1 pathway variant profiling may serve as a useful predictor of individual response to a given therapeutic.

In the combined HOT DNA and RNA datasets the predicted pathway variant nitrate reduction IV included a subset of CDS transcripts for 'nitrate reductase gamma subunit' (24 in DNA, 79 in RNA) while the predicted pathway variant nitrate reduction I included CDS transcripts for multiple nitrate reductase subunits.

This pathway variant is quite different from the canonical pathway known in Enterobacteria, which includes the sucrose-specific PTS-driven uptake and phosphorylation followed by sucrose-6-phosphate hydrolase [ 24].

Finally, we examined 7 well-characterized TLR-pathway variants since previous studies suggest that these SNPs are associated with altered TLR gene function and susceptibility to different infections.