Sentence examples for pathway trail from inspiring English sources
Los Patrones Parkway includes a multi-purpose pathway trail for pedestrians and cyclists that extends from Oso to Chiquita Canyon.
We also observed distinct nucleosomal laddering as a result of chromatin digestion when we treated cells with diphtheria toxin at 150 ng/ml, which is similar to U937 cells that have been treated with the bona fide activator of the extrinsic apoptosis pathway TRAIL (Fig. 3C).
Furthermore, thiazolides sensitize tumor cells to triggers of the mitochondrial (chemotherapeutic drugs) and the extrinsic pathway (TRAIL).
To further confirm the induction of mitochondrial signaling pathway by TRAIL, we also analyzed cytochrome c released from mitochondria into cytoplasm after TRAIL engagement.
Consistent with the role of the PI3K/Akt pathway in TRAIL resistance, we found that loss of PTEN in mouse prostate epithelial cells confers TRAIL resistance whereas the same cells with intact PTEN are sensitive to TRAIL while PTEN+/− cells show intermediate resistance.
Infrastructure-related projects under subparagraph (A) may be carried out on any public road or any bicycle or pedestrian pathway or trail in the vicinity of schools.
(2) Acquisition, construction, maintenance, rehabilitation, and improvement or limited expansion of stand-alone recreation, pedestrian, or bicycle facilities, such as: A multiuse pathway, lane, trail, or pedestrian bridge; and transit plaza amenities.
However, the exact mechanism by which the Akt pathway causes TRAIL resistance is not fully understood.
Apoptosis induction was very similar to the apoptotic pathway after TRAIL treatment.
As previous work demonstrated constitutive activation of the PI3K/Akt signaling axis in HCT116 PIK3CA-mut cells, we evaluated the contribution of this pathway to TRAIL resistance.
Here, we show that targeting of the aberrantly active PI3K/Akt signaling pathway in TRAIL resistant, PIK3CA-mutated CRC cells only partially restored death receptor-triggered apoptosis induction.
