Our results, however, do provide a pathway to DBS collection validation when coupled with the sensitive chemiluminescent immunoassay technique.
This novel in vitro assay provides a realistic human cell based model for basic science studies, identification of new treatment targets, selection of pathways to target validation, and rapid screening of candidate agents.
Demonstration of this CubeSat will provide a low-cost pathway to physical asteroid model validation, shed light on the origin and geophysics of asteroids, and constrain the design of future landers, rovers, resource extractors, and human missions.
The creation of registries for long-term outcomes research and for system validation offers a clear pathway to improvement of the programs.
We have developed a comprehensive biomarker development pathway, extending from discovery through to validation on TMAs, that can yield novel multi-protein panel signatures for use as a prognostic determinant in breast cancer.
Based on these analyses, we will conduct exploratory regression analyses to explore mechanistic pathways to generate hypotheses for future validation.
We explored the feasibility of using the present network model to address known biological phenomena as a pathway toward functional validation of the network.
We selected the PPAR signaling pathway for further validation based on the following criteria: (1) PPAR signaling showed high enrichment in both KEGG gene sets and Reactome gene sets; (2) PPAR pathway has been shown to be involved in neural development and neurodegenerative diseases.
To solve this, around 2003, several attempts were launched to apply model checking approaches to biological pathway validations [ 5- 12].
Although identification of PTMs involved in the Wnt/β-catenin pathway and validation of their function are far from completion in fact a large number of PTMs are not all validated as physiological relevant, the concept that relaying Wnt signal requires dynamic changes in PTM states of the pathway components has been emerged.
Model checking approaches were applied to biological pathway validations around 2003.
