For example, the functionality of a pathway and the status of a dynamic simulation are useful in gaining an overall understanding of the pathway.
This suggested that defects of the mitochondrial function in BCPAP cells may have induced a retrograde pathway modifying the status of cell phosphorylation [29].
This method seeks to assess the activation probability of every circuit, representing a canonical functionality within the pathway, given the status of the sample (e.g., disease, control, etc).
Nucleocytoplasmic trafficking pathways and the status of nuclear pore complex (NPC) components were examined in cells infected with rhinovirus type 14.
Our analysis of enrichment for specific transcription factor binding sites in the altered genes in the presence of vitamin C have indicated changes in the activity of hormone receptor-type transcription factors (like NHR-28 and NHR-76) and of PHA-4, a transcription factors which activity depends on pathways affecting the status of several metabolites and/or nutrients in C. elegans.
As activation of YAP1, the main downstream effecter of the Hippo signaling pathway, results from the inactivation of LATS (large tumor suppressor) and Mst1/2 genes of the Hippo pathway, we evaluated the status of these molecules in Chaetocin-treated samples.
Because rigosertib was previously reported to inhibit PI3K/Akt pathway, we examined the status of phospho-Akt by immunoblotting analysis.
The effects of signalling pathway modulators on the status of intestinal stem cell biology, crypt cell proliferation, migration, differentiation and shedding were determined.
We examined whether loss of PARD6B or PARD6G might promote activation of key proliferation-related signaling pathways and explored the status of protein kinase B1/Akt among several other pathways.
This agrees with the pathway status for the two tumours, defined by β-catenin IHC, with CNS PNET 07 showing nuclear staining and CNS PNET 07R only cytoplasmic.
