Selective repression of Notch pathway target gene transcription.
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain.
Furthermore, the Wnt pathway target genes LGR5 and LGR6, markers of several lineages of stem/progenitor cells, including liver-derived stem cells, were also expressed.
Although the full relationship between ERRs, the transcriptional modulation of insulin pathway target genes, and the AMPK pathway remain to be defined, it appears clear that there is a convergence between these major pathways of energy metabolism.
This review focuses on molecular mechanisms that have been recently reported to mediate selective repression of Notch pathway target gene transcription.
In total, 139 SNPs in eight vitamin D-related pathway target genes were selected for analysis.
The transcriptional coactivator Yki, a phosphorylation target of Wts, regulates the transcriptional control of Hpo pathway target genes [13].
Dkk1 treatment decreased the expression of c-myc, a Wnt pathway target gene, in a dosage-dependent manner (Fig. 5B).
Interestingly, ligand administration did not affect cell growth even though it did upregulate expression of the classic AhR pathway target CYP1A1.
In accordance with GSEA results, Wnt pathway target genes such as Axin2 [24] and c-myc [25] are expressed only in HB1.F3 (Fig. 3C).
Moreover, transgenic expression of an activated Smo allele in the pancreatic epithelium fails to induce Smo pathway target genes or to induce neoplastic change [25].
