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Moreover, TGFB pathway status determines the antiatherogenic effect of estradiol in apoE-/ hypercholesterolemic mice [29].
Multiple measurements in the pathway, including those that are less dependent on the tissue preservation methodology, should give a more complete picture of pathway status and have greater utility as prognostic or predictive biomarkers.
Bayesian fitting of binary probit regression models to the training data then permits an assessment of the relevance of the metagene signatures in within-sample classification, and estimation and uncertainty assessments for the binary regression weights mapping metagenes to probabilities of relative pathway status.
The pathway status was also investigated in a set of medulloblastomas for comparison.
PARADIGM is a tool that infers a pathway status by using known functional structures.
PARADIGM is a tool that infers a pathway status by using a known functional structure [ 4].
For this analysis, we used the copy number alteration data to link unique genetic variants with epigenetic pathway status.
TGFβ and BMP signalling pathway status in cultured human colonic crypts was assessed by phospho-SMAD immunofluorescence.
Fas, the main target of cytotoxic immune cells, and the Fas pathway status may be responsible for such distinction.
In spite of this, there is very little information regarding the mTOR pathway status in aged tissues [ 9; 10].
Correlation between pathway status and subtype are examined and linked to predictions for response to conventional chemotherapies.
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