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The pathway-specific keywords we used include "pathway", "signalling" (and "signalling"), "transduction", "cascade" and "network".
The results displayed in these studies suggest that increased electrophysiological activity in the human brain could be correlated to disturbed, and possibly disinhibited motivational cerebral pathway signalling.
This suggests that the initial stages of hindgut specification do not require JAK/STAT pathway signalling.
All inhibitors prevented activation of FGFR3, and inhibited downstream MAPK pathway signalling.
Such names often contain general pathway-specific keywords ("pathway", "signalling pathway", "cascade", etc).
Such treatment may be able to overcome the activation effect of PIK3CA mutations and block the PI3K pathway signalling.
This suggests that Noonan and LEOPARD Shp2 mutations induce the same phenotype by activating or inhibiting pathway signalling.
Aberrations in other Wnt pathway signalling components in OC have not been investigated in a subtype-specific manner.
TEM was reduced by SIM treatment of PC3-GFP and DU-145, which inhibited Rho pathway signalling.
23 We hypothesised that analysing independent gene expression profiles of diverse oncogenic mutations in BRAF, KRAS or PIK3CA may uncover signatures of activated EGFR pathway signalling.
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In the inverse experiment, we showed that in MCF7 cells with ZNF703 knockdown, inhibition of TGFβ signalling rescues the effect on BrdU incorporation (Fig 5C), suggesting that upon ZNF703 knockdown there is unopposed TGFβ-pathway signalling.
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