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Modules can be more or less cohesive, but their relevance must be seen in relation to the degree at which they communicate, particularly at the pathway scale.
Strategically, not starting with pre-conceived notions, we first conducted a phenotype-specific dissection of IR-induced H2AX-interacting protein network and then performed zoom-in characterization of novel H2AX partners, their H2AX-coordinated interplay on a pathway scale in particular.
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Here, we review the theoretical and experimental strategies for engineering synthetic metabolic pathways at the protein and pathway scales, and highlight the challenges that this subfield of synthetic biology currently faces.
Platelet adhesion and activation of the intrinsic coagulation pathway scaled with the surface composition: the numbers of adherent platelets were highest on the 100%-CH3 100%-CH3whereasurfacereatest contact activation whereasn on 100%-COOH surfaces.
The NGO sector is another option, but it is seldom a viable pathway to scale - for example, the 3.3 million NGOs in India provide less than 1% of the country's health care.
The RBM Global Malaria Action Plan GMAPP) charted the pathway from scale up to elimination.
The end goal of high coverage and quality of maternal and newborn care including KMC is the same, but the entry point and pathway to scale may vary [ 29].
On the other hand, when considering the subcortical hyperintensities in the cholinergic pathways using the Cholinergic Pathways Hyperintensities Scale (CHIPS), Behl et al. showed that patients in the high CHIPS group had improvement in executive functioning and working memory tasks after receiving ChEI therapy for one year [ 28].
Elsewhere, the report emphasizes a change in focus toward ways of improving quality of life for communities: "Community-led and bottom-up approaches offer potentials for climate-resilient development pathways at scale.
These differences are further discussed below considering country pathways to scale and examples of regional networks for implementation.
There are at least a dozen countries worldwide with national KMC programmes, and we identify three pathways to scale: (1) champion-led; (2) project-initiated; and (3) health systems designed.
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