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Moreover, treatment with 30 μM cisplatin elicited the formation of ROS, which, in turn, led to PINK1 activation, parkin recruitment, autophagy formation and JNK pathway relevant to apoptosis in HEI-OC1 cells, HCs, and SGNs.
However, as the bulk of the haplotype resides in AXIN1, a gene in a pathway relevant to heart valve formation,[30] we cannot exclude a role for a primary genetic variant located in either PDIA2, AXIN1, or both as contributing to the observed association with BAV.
Most important is that p66Shc is part of a signal transduction pathway relevant to endothelial integrity.
Interestingly, some differentially expressed miRNAs are involved in the pathway relevant to development and diabetes.
A functional module can be considered as a distinct group of interacting proteins [32] within a pathway relevant to a condition of interest.
The Hu6800 GeneChip™ used in the Golub et al. study surveys only a limited subset of the genes within the genome and has significant gaps in nearly every pathway relevant to understanding the cellular mechanisms that distinguish ALL from AML.
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We are employing forward genetics to identify the pathways relevant to recombination and competition.
Buccella, D. & Janak, K. E. Reactivity of Mo(PMe3)6 towards benzothiophene and selenophenes: new pathways relevant to hydrodesulfurization.
Reaction path analysis and sensitivity analysis were used to explain the pathways relevant to the current studies.
We focus on RNA because CTC transcriptomics is invaluable to evaluate tumor heterogeneity and to define signaling pathways relevant to cancer progression and drug resistance13.
Among activated pathways relevant to macrophage functions, were those linked to CDKN1 (p21Waf, z-score = 2.86), Vitamin D3 (z-score = 4.5) and Irgm1 z-score = 3.45).
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