Reviewers who were responsible for compiling a narrative synthesis for a given pathway read all of the abstracts associated with that tag/pathway, summarized the narrative themes from key articles included as part of that tag/pathway, and highlighted exemplar articles for each theme.
Biologists construct a pathway by reading a large number of articles and interpreting them as a consistent network, but most of the models constructed currently lack direct links to those articles.
It will be of great interest to deter-mine if mitochondrial signals (ROS or otherwise) are instructive in promoting the up-regulation of glycolysis and other metabolic alterations and which signaling pathways are reading out these directly.
Whereas numerous models of visual word recognition postulate the existence of two pathways in reading such as a lexical route and a second one applying grapheme-phoneme conversion rules in order to explain word frequency effect [ 48, 49], our data suggest a more visual-basis effect.
The deep sequencing analysis also allowed us to determine the ratio of Cas9-induced DSBs being repaired by the NHEJ vs HDR pathway (HDR/TE reads).
In a first analysis, we compared pathways for each reading condition thus revealing which pathways are more 'engaged' than others.
These data highlight the autophagy and lysosomal pathways as read outs for pathogenic LRRK2 function and as a marker for disease, and provide insight into the mechanisms linking LRRK2 function and mutations.
For the second purpose of our study, we tested whether the above-described double dissociation in neural pathways could predict reading performance as measured outside the scanner.
The results of the Ruz et al. (2005) study therefore lead us to suggest that intersubject variability in reading pathways may be a consequence of different levels of attention.
That is, skilled readers presented with familiar words presumably emphasize the lexical pathway during the read task, and the phonological pathway during the regularize task.
