Sentence examples for pathway product from inspiring English sources

Very recently, we proposed a novel, pathogenesis-based approach to the treatment of ichthyosis in disorders of distal cholesterol metabolism; 54 i.e., provision of pathway product plus blockade of metabolite production, exploiting this new understanding of disease pathogenesis (Fig. 2 ).

Our previous study has reported that the pentose phosphate pathway product nicotinamide adenine dinucleotide phosphate (NADPH) protected neurons against ischemia/reperfusion-induced brain injury.

Each structure was analyzed for the presence of ligands, the topology and movement of the lid and whether the released product or the biosynthetic pathway product is commercially available.

As such, I was able to generate parasites completely devoid of this essential organelle but chemically rescued by supplementation of the growth media with isopentenyl pyrophosphate (IPP), the pathway product.

If either the drug or the lipid end-product fails to be delivered (suggested by a failure to respond to either pathway product or pathway product ± inhibitor), it is possible that co-applications of inhibitor and lipid product together could interfere with absorption of one or both.

In addition, provision of the pathway product (cholesterol) to avoid epidermal dysfunction due to cholesterol deficiency could also be beneficial by further downregulating (negative feed-back) of HMGCoA reductase activity.

However, most normal cells of the body also need glycolytic pathway products, such as pyruvate, for energy production through OxPhos.

Both HCT and CCR family genes are key enzymes in catalyzing the conversion of phenylpropanoid pathway products into the material for lignin biosynthesis27,29.

These findings demonstrate the feasibility of improving key enzyme activities in important biosynthetic pathways with the aid of designed biosensors of pathway products.

Otherwise, a steady-state could not be maintained and there would be continuous body accumulation of galactose and alternate pathway products.

Conclusion: PAR-2 activation augments uterine contractility in tissues obtained from term pregnant rats, and this effect is independent of mast cell activation or cyclo-oxygenase pathway products.