Sentence examples for pathway point from inspiring English sources

A flurry of domains implicated in the ubiquitination pathway point to a possible connection between ubiqutitination and ADP-ribosylation.

Frequent somatic mutations of genes involved in the nuclear factor-κB pathway point to a more potent role of this signaling cascade in MM than was previously appreciated.

Our discovery of the immediate fusion pathway (point contact to full fusion) raised the hypothesis that for neurotransmitter release, other synaptic proteins introduce a preference for this immediate pathway upon Ca2+-triggering.

The mechanisms involved in an altered AR-signalling of CRPC cells include an over-expression/amplification of the AR (hypersensitive pathway), point mutations broadening ligand-specificity of the receptor (promiscuous pathway) as well as activation of the AR by peptide growth factors or cytokines (outlaw pathway) [ 17].

Results: We examined how dose-dependent responses of zebrafish embryos exposed to flusilazole can be extrapolated, using pathway point of departure data and reverse toxicokinetics, to obtain human oral dose hazard values that are similar to published mammalian chronic toxicity values for the chemical.

FBXO7 is within the same pathway, pointing to mitochondrial maintenance as a therapeutic opportunity [ 68].

By plotting the issues onto the pathway at the point of occurrence, it was possible to identify seven pathway points that warranted further investigation.

Another pathway, the systemic lupus erythematosus pathway, points to that pathogens gain their foothold in host cells through modulating host defense mechanisms [ 25].

For HD, the study of the aggregation pathway pointed to "at least three" aggregation pathways which can be influenced by various inhibitors, molecules, and interactions [ 101].

This induces RAR degradation through the ubiquitin-proteasome pathway, pointing to JNK as a key mediator of aberrant retinoid signaling in lung cancer cells [ 13].

Nevertheless, the accumulating evidence indicating crosstalk between T3 and the AKT pathway points to a complex network involving FoxO3 regulation by T3.