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The latter is a result of the treatment pathway parameters estimated by the clinical experts.
First, we investigated the differentiating pathway parameters between transient and sustained activation of ERK profiles.
In examining the differentiating pathway parameters between the tolerable and intolerable group, parameter k1, i.e. the first reaction rate related to ligand-receptor binding, was found to be the most sensitive one.
Finally, we vary pathway parameters and study how they affect signal and noise transmission.
Therefore, we maintained JAK-STAT signaling pathway parameters constant across species.
The two methods differ in the prior distribution assumed for the pathway parameters.
Similar(48)
Here c is the normalizing constant, and σ is called the pathway parameter.
Let (f in L ( a,b )), (eta in mathbb{C}) with (Re ( eta ) ), (a in mathbb{R}^), and (sigma <1) be the pathway parameter.
Employing effective methods to search and narrow the immense pathway parameter space is essential to meet performance metrics such as high titer, yield and productivity with efficiency.
A control pattern can be understood as a 'chain of local effects' that propagates through a metabolic pathway following a perturbation in a pathway parameter such as enzyme concentration.
LD50 has a strong correlation with the lowest dose at which other toxic effect occurs and can help correct for factors not included in the pathway parameter, including pharmacokinetics.
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