Sentence examples for pathway operation from inspiring English sources

The pathway operation was validated both in vitro and in vivo.

Pathway operation with FAB enzymes was improved through computationally directed protein design to develop FabZ variants with amino acid substitutions designed to disrupt hydrogen bonding at the FabZ-ACP interface and introduce steric and electrostatic repulsion between the FabZ and ACP.

Recently, modelling of regulation at the level of the inhibitor has been performed using differential equations, helping to improve understanding of pathway operation and regulation [14], [15].

In this review article, we will discuss how significant advances can be obtained by applying computational modeling approaches to elucidate the pathways most critically involved in tumor formation and progression, impact of particular mutations on pathway operation, consequences of altered cell behavior in tissue environments and effects of molecular therapeutics.

It has been done quantitatively through the analysis of pathway operations.

To observe real time dynamics, we monitored the localization of NF-κB in single living cells, which are the basic unit for pathway operations and are the definitive context for probing pathway dynamics unambiguously.

Greater appreciation of these pathways' operation will enable the rational redesign of NDP-sugar metabolism to tailor cell wall compositions in Populus in search of an improved biofuel feedstock with less recalcitrant cell walls.

Interestingly, the altered response observed at 1.0-Hz in AF cells from degenerative tissue appears to be independent of either cytokine, suggesting an alternative mechanotransduction pathway in operation.

As the Amoroso RZ fruit did not show any further colour development at room temperature, we may assume that the carotenoid synthesis and catabolism were in equilibrium and that the carotenoid biosynthesis pathway was operation at a steady-state level.

Using arginine-glycine-aspartic acid (RGD) function-blocking peptides, Le Maitre et al. [ 29] showed that the compression-induced decrease in aggrecan gene expression observed in human NP cells occurs through the involvement of integrins in NP cells derived from nondegenerative but not degenerative tissue, suggesting an altered mechanotransduction pathway in operation.

These complexities affect strategic formulations of synthetic biology, optimization designs of systems metabolic engineering, selection of metabolic pathways, and operation process difficulties in the realm of evolutionary engineering at the systems level.